ABSTRACT
AbstractSome publications have described the pharmacological properties of latices proteins. Thus, in the present study proteins from Plumeria pudica Jacq., Apocynaceae, latex were evaluated for anti-inflammatory and antinociceptive activities. Obtained data showed that an intraperitoneal administration of different doses of latex was able to reduce the paw edema induced by carrageenan in a dose-dependent manner (better dose 40 mg/kg; 72.7% inhibition at 3rd and 78.7% at 4th hour) and the edema induced by dextran (40 mg/kg; 51.5% inhibition at 30 min and 93.0% at 1st hour). Inhibition of edema induced by carrageenan was accompanied by a reduction of myeloperoxidase activity. Pre-treating animals with latex (40 mg/kg) also inhibited the paw edema induced by histamine, serotonin, bradykinin, prostaglandin E2, compound 48/80. Additionally, the latex (40 mg/kg) reduced the leukocyte peritoneal migration induced by carrageenan and this event was followed by reduction of IL-1β and TNF-α in peritoneal fluid. The latex-treatment (40 mg/kg) reduced the animal abdominal constrictions induced by acetic acid and the first phase on paw licking model induced by formalin. When latex was treated with heat (at 100 °C for 30 min), anti-edematogenic and myeloperoxidase activities were significantly reduced, indicating the involvement of heat-sensitive proteins on anti-inflammatory effect. Our results evidence that latex fluids are a source of proteins with pharmacological properties.
ABSTRACT
Os paragangliomas são tumores que se desenvolvem a partir dos paragânglios. São raros, têm predominância familiar e malignizam-se em poucos casos. O mais comum é o de corpo carotídeo (0,012% de todos os tumores de cabeça e pescoço). A manifestação clínica mais comum é a presença de massa cervical lateral. Angiografia é o exame de escolha para o diagnóstico do tumor. O tratamento é cirúrgico. Apresentamos o caso de uma paciente com 67 anos de idade, com massa cervical bilateral, assintomática. São descritos a abordagem diagnóstica, os detalhes cirúrgicos e o resultado pós-operatório.
Paraganglioma are tumors that arise from paraganglia. They are rare, there is inheritability and malignancy is also rare. The most common one is carotid body paraganglioma (0,012% of all head and neck tumors). The most common feature is lateral cervical mass. Angiography is gold-standard for diagnoses. Surgical treatment is emphasised. We report the case of a 67 year-old woman with asimptomatic bilateral neck mass. Diagnostic and therapeutic approaches as outcome are described.
Subject(s)
Humans , Male , Female , Aged , Carotid Body Tumor/surgery , Carotid Body Tumor/physiopathology , Carotid Body Tumor/diagnostic imagingABSTRACT
Os lipomas da laringe constituem um grupo de patologias raras, representando aproximadamente 0,6 por cento dos tumores benignos da laringe. Atualmente, existem menos de 90 casos descritos na literatura mundial. Os autores apresentam um caso de lipoma laríngeo localizado na regiäo supraglótica em um paciente do sexo masculino, queixando-se de dispnéia de decúbito, engasgos e sensaçäo de corpo estranho na garganta. Enfatizam os métodos diagnósticos e o tratamento microcirúrgico realizado